BMS 833923
- Product Name
- BMS 833923
- CAS No.
- 1059734-66-5
- Chemical Name
- BMS 833923
- Synonyms
- XL139;CS-944;XL-139;XL 139;BMS 833923;BMS-833923 (XL-139);BMS 833923 USP/EP/BP;BMS 833923; BMS833923; XL-139; XL139; XL 139;N-[2-Methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenylquinazolin-2-yl)amino]benzamide;Benzamide, N-[2-methyl-5-[(methylamino)methyl]phenyl]-4-[(4-phenyl-2-quinazolinyl)amino]-
- CBNumber
- CB42658184
- Molecular Formula
- C30H27N5O
- Formula Weight
- 473.57
- MOL File
- 1059734-66-5.mol
BMS 833923 Property
- Density
- 1.252±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- ≥47.4 mg/mL in DMSO; insoluble in H2O; ≥5.14 mg/mL in EtOH with gentle warming and ultrasonic
- form
- solid
- pka
- 13.42±0.70(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 16240
- Product name
- BMS 833923
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- 16240
- Product name
- BMS 833923
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $109
- Updated
- 2024/03/01
- Product number
- 16240
- Product name
- BMS 833923
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $194
- Updated
- 2024/03/01
- Product number
- 16240
- Product name
- BMS 833923
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $317
- Updated
- 2024/03/01
- Product number
- B596320
- Product name
- BMS833923
- Packaging
- 100mg
- Price
- $395
- Updated
- 2021/12/16
BMS 833923 Chemical Properties,Usage,Production
Description
Smoothened (Smo) is a cell surface receptor that, with Patched, mediates sonic hedgehog (Shh) signaling to regulate gene expression through the Gli transcription factors. BMS 833923 is an orally bioavailable inhibitor of Smo. It blocks binding of BODIPY cyclopamine (IC50 = 21 nM) and inhibits Gli activation in cell lines that express wild-type Smo or activated mutant forms of Smo (IC50s = 6-35 nM). BMS 833923 robustly inhibits Shh pathway activity and prevents tumor growth in medulloblastoma and pancreatic carcinoma xenograft models.
Uses
BMS 833923 is an antagonist of smoothened, a key hedgehog (Hh) pathway regulator.
BMS 833923 Preparation Products And Raw materials
Raw materials
Preparation Products
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